Oxenfree II: Lost Signals (Night School Studio) is a narrative adventure game about Riley, a 32-year old woman who returns to her home town to work on a local project to monitor signals in the area. Partnered with Jacob Summers, she is tasked with placing transmitters at strategic points in the remote hillsides. Planting the first transmitter results in a sudden burst of light and launches the characters into a deep mystery full of ghosts, a local cult, and inter-dimensional time travel.

Lost Signals expands on the mechanics from the first game. As before, the player can use the radio tuner to tune into strange frequencies and interact with supernatural elements, but they can also use the radio throughout the night to listen to news and music on various stations, which might provide helpful information. In addition, the player can use a walkie talkie to connect with various people, learn about them and their lives, and receive and give aide.